CASPASE IN PEPTIC ULCER

نویسندگان

چکیده

Peptic ulcer disease (PUD) is when gastric mucosa gets injured due to the increase of acid and pepsin enzyme. The common risk factors are infection Helicobacter pylori bacteria misused NSAIDs. This review article aims describe role caspase in PUD. Methods used selection articles PubMed. Caspase a protease enzyme that plays an apoptotic inflammatory reaction can be activated dimerized or cleaved. Caspase-3, caspase-6, caspase-7, caspase-8, caspase-9 divided into two subgroups for group. Caspase-1, 4, caspase-5 part inflammation Some compounds inhibit modulateit. Moreover, most them work being inhibitors avoid Caspase-1 holds high responsibility activate other caspases.

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ژورنال

عنوان ژورنال: Jurnal Ilmiah Farmako Bahari

سال: 2022

ISSN: ['2087-0337', '2715-9949']

DOI: https://doi.org/10.52434/jfb.v13i2.1266